The effect of early measles vaccination on morbidity and growth: A randomised trial from Guinea-Bissau
نویسندگان
چکیده
منابع مشابه
Effect of early measles vaccine on pneumococcal colonization: A randomized trial from Guinea-Bissau
BACKGROUND Measles vaccine (MV) may have non-specific beneficial effects for child health and particularly seems to prevent respiratory infections. Streptococcus pneumoniae is the leading cause of bacterial pneumonia among children worldwide, and nasopharyngeal colonization precedes infection. OBJECTIVE We investigated whether providing early MV at 18 weeks of age reduced pneumococcal coloniz...
متن کاملThe effect of early measles vaccination at 4.5 months of age on growth at 9 and 24 months of age in a randomized trial in Guinea-Bissau
BACKGROUND Providing an early, additional measles vaccine (MV) at 4.5 months of age has been shown to reduce child mortality in low-income countries. We studied the effects on growth at 9 and 24 months of age. METHODS A randomized controlled trial was conducted in Guinea-Bissau from 2003-2007 including 6,648 children. Children were randomized 1:1:1 to receive Edmonston-Zagreb measles vaccine ...
متن کاملEffect of revaccination with BCG in early childhood on mortality: randomised trial in Guinea-Bissau
OBJECTIVE To determine whether BCG revaccination at 19 months of age reduces overall child mortality. DESIGN Randomised trial, with follow-up to age 5. SETTING A health project in Bissau, Guinea-Bissau, which maintains a health and demographic surveillance system in an urban area with 90 000 inhabitants. PARTICIPANTS 2871 children aged 19 months to 5 years with low or no reactivity to tub...
متن کاملEffect of an Early Dose of Measles Vaccine on Morbidity Between 18 Weeks and 9 Months of Age: A Randomized, Controlled Trial in Guinea-Bissau
Background Children in Guinea-Bissau receive measles vaccine (MV) at 9 months of age, but studies have shown that an additional dose before 9 months of age might have beneficial nonspecific effects. Within a randomized trial designed to examine nonspecific effects of early MV receipt on mortality, we conducted a substudy to investigate the effect of early MV receipt on morbidity. Methods Chil...
متن کاملEarly two-dose measles vaccination schedule in Guinea-Bissau: good protection and coverage in infancy.
BACKGROUND Previous studies from Africa have suggested that there is little benefit to be gained from early two-dose measles vaccination schedules. Two-dose schedules have been associated with no improvement in coverage due to immunization of the same individuals on both occasions, low return rate, high refusal rate, low vaccine efficacy, and fear of blunting of the antibody response. Because o...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2020
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2020.01.096